NFL News: 49ers rule out quarterback Brock Purdy due to a toe injury against the Buccaneers
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San Francisco 49ers quarterback Brock Purdy and wide receiver Ricky Pearsall have been ruled out of the team’s game against the Tampa Bay Buccaneers on Sunday.
Purdy is absent due to a toe injury, while Pearsall is absent due to a knee injury.
Backup quarterback Mac Jones, listed on the injury report as questionable, is expected to start for the 49ers. Jones suffered an oblique injury on his final play in last week’s overtime win over the Los Angeles Rams and was limited all week in practice, but should be ready to play, according to head coach Kyle Shanahan.
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San Francisco 49ers quarterback Brock Purdy (13) after the game against the Jacksonville Jaguars at Levi’s Stadium in Santa Clara, California, on September 28, 2025. (Darren Yamashita/Imagine Images)
Purdy, 25, initially injured his toe in the season opener against the Seattle Seahawks. He missed the next two games and returned to play in Week 4 against the Jacksonville Jaguars, but aggravated the injury and missed last week’s game against the Los Angeles Rams.
Purdy, who signed a five-year, $265 million extension this offseason, will miss his sixth game with injury in San Francisco’s last 13 games dating back to last season.
While the 49ers certainly miss Purdy, they haven’t missed a beat with Jones, as they are 3-0 in his starts.
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San Francisco 49ers wide receiver Ricky Pearsall (1) before the game against the Jacksonville Jaguars at Levi’s Stadium in Santa Clara, California, on September 28, 2025. (Darren Yamashita/Imagine Images)
The 27-year-old has completed 66.7% of his passes for 905 yards with six touchdowns and one interception in three games.
Jones is one of only two quarterbacks — along with Matthew Stafford in 2021 with the Rams — to win his first three starts with the franchise while throwing for at least 900 yards and six touchdowns.
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San Francisco 49ers quarterback Mac Jones reacts during the second half of an NFL football game against the Los Angeles Rams, Thursday, Oct. 2, 2025, in Inglewood, Calif. (Brian Rothmueller/Sportswire Icon via Getty Images)
However, for the second week in a row, Jones won’t have Pearsall to throw to. Jauan Jennings, one of Jones’ top targets, was listed as questionable with ankle and rib injuries that kept him out of last week’s game.
The 49ers (4-1) play the Buccaneers (4-1) at 4:25 PM ET on Sunday.
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