The main genetic differences in people with chronic fatigue syndrome

Genetic factors that can contribute to the risk of developing chronic fatigue syndrome (CFS), also known as muscle encephalitis (ME), have been identified in a large study. Scientists have linked eight areas of human genome to the situation, based on DNA samples of more than 15,000 people.

“Our study provides the first strong evidence of the genetic contributions to me,” he says, says Sonia Chaudhry At charitable work for me in the United Kingdom.

In the long run, the results can contribute to the development of new diagnostic tools and treatments for me/CFS, which have been recognized for decades and are mainly distinguished by feeling uncomfortable after the procedure, which is a severe and talented response even even the moderate effort.

But already, the results provide “health and credibility” for people who suffer from the condition, says Ch Xodry. “Many people have suffered from comments like” I am not real. “” They went to the doctors and how they were told that it is not a real disease, “she says.

“This will be huge for the sick population,” he says. Andy Daviro CookParticipating founder for Science for me The forum, which was subjected to the condition for 45 years.

The study, called DecodemeDNA has compared more than 15,500 people with me/CFS and about 260,000 without them, all of them from the United Kingdom and European origins.

He says, “We have found eight genetic signals.” Chris Pontang At the University of Edinburgh in the United Kingdom. The eight concerned genome areas appear significantly different in people who have/CFS, indicating that genetic variables there contribute to the risk of developing it. Edinburgh University has announced the results at a press conference, but it has not yet been published in a magazine or on a pre -printing servant.

Inside these eight areas, the team identified 43 gene encodens, 29 of the genes in particular looked. “When we dig in these eight different genetic signals, we find genes associated with the immune system and the nervous system,” says Pontang. “In general, the activities of the genes in these signals in the brain tissue are more likely to be more active in the brain than anywhere, indicating the nervous system’s participation.”

The researchers also identified a gene associated with immunity rabgap1l As a possible contribution to the risk of Me/CFS. This is suitable for the testimony of most people who suffer from this condition, who say the initial infection, which often looked moderate, precedes their symptoms.

“My idea has always been something different from the immune system of people with me/CFS.” Jackie Cliff At the University of Bronil, London, which adds that the study is “a good jump forward in the ME/CFS search.”

The work found no differences in genetic risks between men and women, although Me/CFS is more common in women. However, the team has not yet analyzed the X and Y.

The next step is to study the eight regions of the genome that is highlighted in more detail, to try to know how to translate genetic changes into molecular and cell operations in people who suffer from and without CFS. This may one day lead to diagnostic tests and drug treatments targeting the basic mechanisms of the condition. However, this will only happen if the research financiers support it. “There is an absolute scarcity of financing,” says cliff.

Great damage to me/CFS, with appreciation 67 million people are affected by it all over the world. The 2017 report was issued by the tank 20/20 Health The UK economy costs 3.3 billion pounds annually In health care and productivity loss. “It is forgotten disease and its backwardness, and therefore, it deserves a lot of people’s attention and investment,” says Poning.

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