Good immunity health may come at the expense of chronic inflammation

The presence of a strong immune system may come enough to live a longer life at the expense of chronic inflammation. Some immune cells are subject to a form of inflammatory death that have evolved to protect us from infections, but they sometimes do a random time, when there is no cause of pathogens, which leads to continuous inflammation associated with a set of health complications.

Our innate immune system includes a group of cells that quickly respond to invasive diseases, such as viruses and bacteria. These cells usually feel microbes when they take fragments from them or get injured.

“Based on a little information, such as a viral DNA molecule, the immune cell actually has just a few minutes to determine what to do, and the decision is often the killing of itself; a kind of this altruistic suicide that inflates the signs of inflammation.” Randal Havman At the Kansas University Center for Cancer.

We have already known that this form of cell death, which is called pyroptosis, is operated by the domain of death proteins. These usually float in fungal immune cells, but when they come into contact with the nurse, they gather in crystals -like structures. Then this protein is activated that kills the cell by hitting holes in it, causing rupture and release of inflammatory signals that help the immune system to remove the nurse.

To better understand this process, Halfmann and his colleagues made a series of laboratory experiences where they studied human death proteins in yeast cells. This allowed them to define five types of these proteins with chemical properties that would make them more vulnerable to forming crystal -like structures automatically when there are no pathogens. Then the researchers used the data that was previously collected to determine the levels of these proteins in the uninfected human immune cells.

From this, they calculated that some fungal immune cells-such as the supplies, which swallow and destroy pathogens-contain the five domain proteins of death at high levels enough that can assemble automatically to operate cell death in the body. Halfmann says: “If they are highly high concentrations, it is likely that the molecules will be randomly gathering in the crystalline structures at some point during the cell age,” says Halfmann.

Halfmann says that such events may contribute to chronic inflammation, which builds with age and has been linked to different conditions, such as cancer and Alzheimer’s disease. “It seems that we have developed this way to survive, but this may come at the expense of chronic inflammation,” he says.

This path protects us from infections that pose a threat from birth, which gives us a greater opportunity to live in old age, but this may also mean that we are facing a disease associated with inflammation in subsequent life, says Halfmann. He says these small fires explode throughout life, the inflammatory damage that occurs may accumulate over time. ” Andy Clark At the University of Birmingham, UK.

Halfmann says that the development of drugs that prevent cells from death automatically can reduce age -related chronic inflammation. But Clark indicates that this will make people more likely to develop infections, a preference that may not always deserve to be made.

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