One blood sample can reveal the age of 11 members and your systems

A single blood test can reveal the biological ages of 11 different organs and physical systems, which may highlight the risk of disease in those areas.

“The goal is to take care of a single test that not only shows the general biological age, but the systems that lead it,” he says. Raghav Sehgal At Yale University. “In this way, people can obtain specific recommendations for life or treatment based on their unique profile.”

To measure the longevity of a person or the risk of developing his illness, it helps to know his biological age – how quickly their bodies agreed – unlike one time, he says. Morgan Levin At Altos Labs in California. To find this, scientists have developed genetic watches that decompose the DNA – the process in which the DNA adds or removes chemical signs that help to replace different genes on and stop them.

Levin says he is useful, but he lacks accuracy. It says that our members and systems are at different rates, depending on our genetics and medical history.

“There is awareness that members and systems within the individual may advance differently,” he says. Vadim Gladchif At Harvard University, who did not participate in the study. “Some people may be older in the brain, others in the kidneys, some of them are in multiple organs, compared to the rest of the body.”

So, Sehgal and Levine and their colleagues began developing an likely test that focuses on the state of aging for different parts of the body. First, they reviewed blood tests, medical history and physical measurements, such as a fist force, of about 7,500 people whose data were collected as part of two research programs: health and retirement study – a database of people in the United States over the age of 50 – and a Heart Heart study, part of which includes families in the United States to search for DNA genetic research.

Then the scientists searched for any clear links between the vital indicators of blood and the conditions associated with age associated with five members-the heart, lung, kidneys, liver and brain-six systems-immune and inflammatory systems, blood, muscles, random structure, hormone and metabolism. Then they connected these results to the patterns of DNA, and they trained the computer model to identify these patterns and calculate the biological age of each member or system, in addition to providing a general biological age.

Once their model is trained, the researchers tested on the blood from 8125 additional people, their data were used in four other studies. They found, for example, that the degree of heart of their model can predict heart disease, and follow the degree of the brain with cognitive decline and that the degree of muscles and bones reflect whether people have cases such as arthritis.

When tested against the current Lagin watches, the grades of the organ/system were at least accurate, and often better, according to researchers. “It is striking to some extent that we can correctly estimate aging across many systems by measuring one thing in the blood test,” Levin says.

Daniel Bilelsky The University of Colombia in New York says this watch represents the “values” in Jerusus science, the study of aging. He says: “This is the first genetic watch to look at multiple systems within the body simultaneously and move towards the idea of ​​an explanatory measurement of biological aging that can be tracked into tissues in a organ,” he says. “This would give us a way to work back from a brief measurement towards the location inside the body where the appearance of the closest pathology is.”

But he warns that such an approach may start from the general goals of this field. “The idea of ​​gyroscope and the promise of aging biology made us in the past thinking about humans as a group of independent working parts in which we try to find the weakest link and its support to prevent failure, and thinking about the organism as an integrated person,” says Bilsky. “I think it is important not to lose sight of that original vision.”

More importantly, the test is not intended to use it for diagnosis, but to assess risks, says Levin. “All these tests – like tests in our study – aims to provide estimates and provide some ideas about what is going on in our bodies,” she says. “Over time, researchers should be able to develop more clear and powerful estimates of the aging process, probably by integrating many different measures to capture insecurity and complicate the aging process.”

Gladyshev hopes that the research will lead to the strategies dedicated to the disease. “This is the main effects of this line of search.” But Pilsky adds that more studies are needed. “We are not there yet.”

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