Rams vs. Jaguars odds, expert picks and predictions for the 2025 NFL London game
The teams competing for the top spot in their respective division meet when the Los Angeles Rams take on the Jacksonville Jaguars in London, England, on Sunday morning. Los Angeles is coming off a 17-3 win over Baltimore, while Jacksonville dropped a 20-12 decision to Seattle last week. The Rams (4-2), who are tied for the NFC West lead, are 2-1 on the road this season. The Jaguars (4-2), who are one game behind the Indianapolis Colts in the AFC South, are 3-1 as the home team in 2025. Los Angeles wide receiver Puka Nacua (ankle) has been ruled out.
Kickoff from Wembley Stadium is scheduled for 9:30 a.m. ET. The Rams lead the all-time series 5-1, including wins in each of the last three meetings. The Rams are three-point favorites in the latest Jaguars vs. Rams, while the over/under total points scored is 44.5. Before making any choice between the Rams and Jaguars, Be sure to check out the NFL predictions from SportsLine NFL expert Larry Hartstein.
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A former head writer for Covers and the Linemakers, Hartstein combines an extensive network of Vegas sources with an analytical approach he honed while working at Pro Football Focus. Hartstein tied for 52nd place (out of 1,598 entries) in the 2022 Westgate Las Vegas SuperContest, going 53-34-3 ATS. He is coming off the 2024 NFL season at SportsLine which puts him 967-821 all-time on NFL sides and cornerbacks (plus 13.8 units), including 593-518 ATS. Entering the 2025-26 season, he has been profitable in five of six seasons, going 659-564 ATS (plus $3,556 for $100 players).
Additionally, Hartstein is 27-11 in his last 38 picks including the Rams, returning more than $1,300. Anyone who keeps track of their NFL bets at sportsbooks and betting sites can see strong returns.
Now, Hartstein has his sights set Rams vs. Jaguars He is only locked in his choices and expectations. You can head over to SportsLine now to see his picks. Here are several NFL odds and betting lines for Rams vs. Rams. Jaguars:
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Rams vs. Jaguars spread |
Los Angeles -3 at DraftKings Sportsbook |
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Rams vs Jaguars Over/Under |
44.5 points |
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Rams vs. Jaguars money line. |
Los Angeles -161, Jacksonville +135 |
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Picks Rams vs. Jaguars |
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Rams vs. Jaguars streaming |
Fubo (Try for free) |
Why the Rams can win
Veteran quarterback Matthew Stafford has gotten off to a strong start to the season. In six games, he completed 139 of 209 passes (66.5%) for 1,684 yards, 12 touchdowns and two interceptions for a 106.2 rating. In a 26-23 overtime loss to the 49ers on October 2, Stafford threw for 389 yards and three touchdowns. He completed 29 of 41 passes for 375 yards and three touchdowns in a 27-20 win over the Colts on September 28.
Also helping to lead the offense is fourth-year veteran running back Kyren Williams. In six games, Williams rushed 95 times for 418 yards (4.4 average) and two touchdowns. He has a long 20-yard run and has converted 26 first downs. He also has 18 receptions for 155 yards and three touchdowns. In the win over the Ravens, he carried 13 times for 50 yards and a score. Find out which team you’ll be supporting at SportsLine.
Why the Jaguars can win
Quarterback Trevor Lawrence is the key to Jacksonville’s offense. In six games, he has completed 61.1% of his passes for 1,324 yards and eight touchdowns. He was selected five times and had an 81.9 rating, but he also rushed 28 times for 95 yards and two scores. In the loss to Seattle, he completed 27 of 42 passes for 258 yards and two touchdowns.
Running back Travis Etienne Jr. leads the ground attack. He carried 89 times for 470 yards (5.3 avg.) and two touchdowns. He had three explosive plays of 20 yards or more, including a 71-yarder, with 16 first-down conversions. In a 26-21 win at San Francisco on September 28, he rushed 19 times for 124 yards and one touchdown. He had 14 carries for 71 yards in a 31-27 season-opening loss at Cincinnati. Find out which team you’ll be supporting at SportsLine.
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How to pick the Rams vs. Jaguars
Hartstein analyzed the Rams vs. Jaguars from every angle and is leaning toward the point total. He also discovered the crucial X-factor that kept him jumping to one side of the space. He shares just what it is, and which side to support, at SportsLine.
Who will win the Rams vs. Jaguars matchup, and what is the deciding factor that makes either side of the spread a must-have? Visit SportsLine now to see which side the Rams vs. Jaguars you need to jump on, all from the veteran who is 27-11 in his last 38 picks with the Los Angeles RamsAnd find out.