Scientists find a link between genes and me/chronic fatigue syndrome I / chronic fatigue syndrome
Scientists have found the first strong evidence that people’s genes affect their chances of developing muscle encephalitis or chronic fatigue syndrome (Me/CFS), a mysterious and weak disease that has been neglected and rejected for decades of time in medical society.
The early results of the world’s largest study in the genetics of the case of eight regions of the human genome that were a great difference in people suffering from the ME/CFS diagnosis compared to those who have no disease.
This discovery indicates that many variables of genes usually in the population raises the risk of developing the disease, although many people will carry the variables and never acquire it.
Professor Chris Poning, a researcher in Decodi Study at the University of Edinburgh, described the results of a “waking up” invitation that showed that genetics for a person can “raise the balance” about whether they will develop Me/CFS.
“This provides the first strong evidence of the genetic contributions to me,” said Punting. “There are many genetic variables that apply across the genome that prepare people to be diagnosed with me.”
More research is needed to develop diagnostic tests or offers to determine people at a great risk of Me/CFS. But scientists have described the work as a prominent sign that puts the disease equally with other exhausted diseases and opened possible ways of treatments.
“This really adds the authority and credibility of people with me,” said Sonia Chaudhry, CEO of Action for Me and Decdeme. “We know that many people have suffered from comments such as” I am unrealistic. “
Despite its long history, scientists only understand the causes of Me/CFS, although most patients report an infection before symptoms first appear. Typical symptoms include severe fatigue, sleep problems, brain fog and exacerbation of symptoms after physical or mental activities, known as distress after the procedure, which may take weeks to recover from them.
It is estimated that 67 million people are affected by Me/CFS at an annual cost of the global economy of tens of billions of pounds. In the United Kingdom, the annual economic outcome is calculated in More than 3 billion pounds. There is no test or treatment for the disease.
Decodee, a cooperation between Edinburgh University, ME charities and patients, was launched in 2022 to explore whether genes play a role in those who develop Me/CFS. For the latest business, the researchers analyzed 15,579 samples of 27,000 DNA with Me/CFS and more than 250,000 people without illness.
The eight genetic areas that have emerged in people with/CFS contain genes involved in immune defenses and nervous system. It will take more work to penetrate in biology, but some genetic variables may make people more vulnerable to me/CFS by prejudice to their ability to fight bacterial and viral infections. Another genetic difference in Me/CFS is known from people with chronic pain, which is one of the symptoms that many suffer from Me/CFS as well. “In general, what is happening here is that genetics is in line with how people described their disease with me,” Puntng said.
Andy Daviro Cook, a participant in the joint response, said the results will be huge for patients. He said: “The vast majority of the sick population has been abandoned mainly in one way or another by families, government and medical system.” “This will be huge for the sick population. Although it does not provide all answers [and] It does not provide practical help, it is a welcome decrease in the ocean towards the heart of the tide. “
Among the many questions that remain the reason that Me/CFS affects much larger women. Diagnosis is four times more common in women, but the study did not find any genetic interpretation. Another question is whether the long interfere with me/CFS. While many symptoms are similar, researchers have found no genetic link between the two. “One of the main things we do is to enable others to use their different methods to ask the same question and answer it,” Poning said.
Professor Ann McCardel, who is studying Me/CFS at the University of Liverpool, said the results, which have not yet been published in the Journal of Laysee, presented a “strong basis” for future work that we hope will help accelerate the development of a treatment for destroyed diseases.
Dr. Beta Godska, who studies Me/CFS at Oxford University, has recently used the MRI to survey the brain brains with Me/CFS and long Covid. Those who are with me/CFS but not long He had high levels of lactate in the front belt dandruffA brain area that merges information about effort and emotion. This indicates the disruption of energy metabolism in the brain, the weakness of mitochondria, the battery -like structures that provide energy within the cells.
Godwska said: “It is a very sad fact that the people with me/CFS are still not believers and that the disease has been very neglected, especially when it comes to research financing. We hope this study will come with the benefit of fighting the stigma, and persuading the financiers research that this is a real biological condition.”