The foundations of eczema may start in the womb

Stress during pregnancy, perhaps a sign of 6 to 8 months in particular, may increase some immune cells in the skin of the fetus to exaggeration, which leads to eczema.

The immune cells are called mast cells in the skin of histamine and other chemicals that lead to redness, swelling and itching during allergic reactions. Eczema is not a kind of allergy, but these chemicals themselves can help fuel the infections that stimulate it in response to irritating, coarse or wet materials, such as soap, detergents and detergents.

A series of experiments on mice now showed that the bastard cells become very interactive when the fetus is exposed to stress hormones in the womb.

He says that the experiences of the emotional pregnant women can have an impact on the health of their children: “Something that our work really raises is that the emotional experiences of pregnant women can have an impact on the health of their children.” Nicholas Godinzio At the Toulouse Institute of Infectious Diseases and infections in France. “Making mothers feel guilty not at all to be the goal of this research. This may be more than a message for women’s partners and their support systems.”

Previous research It has been suggested that there is a link between stress during pregnancy and eczema in newborns. To understand the mechanisms behind this, Gaudenzio and his colleagues conducted experiments on dozens of pregnant mice.

Some were placed under pressure by placing them in tight tubes with bright lights that shine on it for half an hour, three times a day for five days. The researchers specifically targeted the third and third third, early, a decisive window for the development of immune and nervous systems. They found that the levels of stress hormone in mice increased in both the bloodstream and the amniotic fluid during this period.

After the birth of the puppies, the researchers either simulated the wearing of diapers by placing drowned pads in a saline solution on their backs or gently rubbing the adhesive tape behind their knees and in the bends of the elbows – the hot eczema dots.

They found that all the descendants of tension mothers developed an eczema-like rash that was red, itching or scaly in those sites, while those born to control mothers-who were free to wander around the cage during pregnancy-sometimes showed slight irritation, but they have never had complete pests.

The RNA sequence of sensory neurons that connect the skin to the spinal cord revealed that approximately 300 gene was expressed in a different way in the offspring of stressful mice, many of which are associated with pain, touch and itching, indicating the high sensitivity of the skin. The reaction of the puppies born to mothers more stretched over cute communication, such as being unloaded with fine nylon threads.

The immune cells sequence of the skin of puppies showed 500 genes expressed differently in the mast cells. Under the microscope, this looked as if they were preparing to release histamine. “They were already active in rest, in a neutral environment, which means that the skin is exposed to the development of inflammation,” says Godinzio.

The researchers repeated their experiences in the pregnant mice that were treated with medicines that prevent them from creating corticosterone, a hormone that plays an important role in responding to stress in rodents, and these eczema did not have. They also gave an additional corticosterone to pregnant mice that were not in exhausting situations – Al -Jaqi developed eczema.

Then the researchers designed the puppies genetically to completely lack the bastard cells. These eczema animals did not evolve, even when their mothers were emphasized.

“It is a very comprehensive and interesting study,” he says. Thomas BloomWhich specializes in cellular science at the German Cancer Research Center in Heidelberg. “It emphasizes this new opinion in the field, at the level of tissues, the interactions between immune cells, structural cells and the nervous system everywhere and they really play important roles.”

However, it is important to keep in mind that experiments were conducted on mice. “It is interesting, but it is just a first foot in the door,” says Bloom.

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