The start of HRT in early menopause may reduce the risk of Alzheimer’s

It seems that hormone therapy (HRT) within five years of the beginning of menopause reduces the risk of Alzheimer’s disease. However, it seems that starting later in life has an opposite effect, indicating that the HRT timing affects how it affects the brain.

Women suffer from the risk of developing Alzheimer’s disease compared to men, especially after menopause. This may be due to a decrease in estrogen hormone, which regulates energy and brain production. As such, HRT has emerged as a potential tool to relieve Alzheimer’s risk after menopause. But studies on their effectiveness showed mixed results.

So Fnu vaibhav At the University of Pandit in the Dayal Sharma Hygienia in India, his colleagues analyzed Al -Zheimer’s incidents through 53 studies, which total more than 8.4 million people. All the participants were after menopause.

They were found in experiments randomly, and on average, he found 38 percent greater risk of Alzheimer’s disease than those who were not. But this was not the case with observation -based studies, which showed 22 percent fewer risk of Alzheimer’s disease among those who take hormone compensation.

Vaibhav, who presented these results on September 15th at a meeting of the American Neurological Association in Maryland, says the blatant contrast may return to age. He says that most of the participants in the trials that are randomly were 65 years or older, while those in observation studies tend to be younger. More analysis showed, on average, that those who started HRT within five years of menopause had a 32 percent fewer risk for Alzheimer’s disease through follow -up periods that ranged between five years in some studies to a person’s life to death in others.

“This menopause is actually nervous transmission,” he says, says Roberta Bernon At Arizona University, which did not participate in the research. As estrogen levels are low, the brain must find new ways to produce energy. Some evidence indicates that the brain may pressure itself, using important compounds to maintain the function of the brain as fuel, and may lead nervous degeneration. Bernon says that the start of HRT during menopause or shortly after this shift may stop. But if the brain has already led to this transition, it may be too late for HRT to have an effect, she says.

“We need more studies to know the solution to this confusion,” says Vibahv. It is without a clearer understanding of the effects of hormone compensatory therapy, “women may lose benefits, or women may be in harm,” he says.

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